GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1577917 | 1 | rs6914463 | chr6:86653415 | SNHG5 | chr6:86386726-86388451:- | -0.53 | -12.62 | 1.01E-31 | Response to antipsychotic treatment |
| THCA | cis | rs9369898 | 1 | rs6915187 | chr6:49423547 | CENPQ | chr6:49431096-49460820:+ | -0.33 | -6.99 | 9.56E-12 | Homocysteine levels |
| THCA | cis | rs6911965 | 1 | rs6916802 | chr6:24465722 | GMNN | chr6:24775159-24786276:+ | -0.27 | -3.61 | 0.000342 | Hematological and biochemical traits |
| THCA | cis | rs6911965 | 1 | rs6916802 | chr6:24465722 | GPLD1 | chr6:24428405-24489850:- | 0.25 | 4.63 | 4.73E-6 | Hematological and biochemical traits |
| THCA | cis | rs6911965 | 1 | rs6916802 | chr6:24465722 | MRS2 | chr6:24403153-24425809:+ | 0.24 | 5.43 | 8.87E-8 | Hematological and biochemical traits |
| THCA | cis | rs9369898 | 1 | rs6916888 | chr6:49383804 | CENPQ | chr6:49431096-49460820:+ | -0.32 | -6.83 | 2.6E-11 | Homocysteine levels |
| THCA | cis | rs9369898 | 1 | rs6918347 | chr6:49406348 | CENPQ | chr6:49431096-49460820:+ | -0.32 | -6.85 | 2.3E-11 | Homocysteine levels |
| THCA | cis | rs6918586 | 1 | rs6918586 | chr6:26097384 | BTN3A2 | chr6:26365398-26378546:+ | -0.2 | -5.32 | 1.6E-7 | Schizophrenia |
| THCA | cis | rs9378357 | 1 | rs6918838 | chr6:3286134 | PSMG4 | chr6:3259162-3268300:+ | 0.3 | 6.62 | 9.66E-11 | Obesity-related traits |
| THCA | cis | rs6919210 | 1 | rs6919210 | chr6:70589630 | COL19A1 | chr6:70576448-70922157:+ | -0.27 | -4.1 | 4.9E-5 | Subjective well-being |
| THCA | cis | rs751728 | 1 | rs6920075 | chr6:33731797 | LEMD2 | chr6:33738991-33756906:- | -0.3 | -6.87 | 1.95E-11 | Crohn's disease |
| THCA | cis | rs9346353 | 1 | rs6920280 | chr6:70489142 | LMBRD1 | chr6:70385751-70506888:- | -0.1 | -3.37 | 0.000826 | Sleep duration |
| THCA | cis | rs943466 | 1 | rs6921487 | chr6:33749293 | LEMD2 | chr6:33738991-33756906:- | 0.24 | 5.15 | 3.74E-7 | Body mass index |
| THCA | cis | rs9467160 | 1 | rs6922313 | chr6:24438719 | MRS2 | chr6:24403153-24425809:+ | -0.16 | -4.53 | 7.31E-6 | Liver enzyme levels |
| THCA | cis | rs9467160 | 1 | rs6922631 | chr6:24438734 | MRS2 | chr6:24403153-24425809:+ | -0.17 | -4.65 | 4.39E-6 | Liver enzyme levels |